Tien Hsien Liquid

Tien Hsien Research Study Published in American Journal of Chinese Medicine

Title:	Immunomodulating Effects of "Tien-Hsien Liquid" on Peripheral Blood Mononuclear Cells and T-Lymphocytes from Patients with Recurrent Aphthous Ulcerations
Source:	The American Journal of Chinese Medicine, Vol. 32, No. 2 (2004) 221-234
Copyright:	World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine
Author(s):	Andy Sun Institute of Microbiology, College of Medicine, National Taiwan University, ROC Jean-San Chia Institute of Microbiology, College of Medicine, National Taiwan University, ROC Won-Bo Wang Institute of Microbiology, College of Medicine, National Taiwan University, ROC
Abstract:	Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-stimulated proliferation response (PR) of peripheral blood mononuclear cells (PBMC) and T-cells isolated from RAU patients and to test whether THL is a potential drug for treating RAU, PBMC or T-cells isolated from RAU patients were incubated with lipopolysaccharides (LPS) from Escherica coli, phytohemagglutinin (PHA), staphylococcal enterotoxin B (SEB), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. We found that THL significantly increased the LPS-stimulated PR of PBMC from active RAU patients, the GtfD-stimulated PR of PBMC and of T-cells from inactive RAU patients, and the S. mutans-stimulated PR of PBMC from inactive RAU patients. However, THL could also significantly reduce the SEB-stimulated PR of PBMC and of T-cells from active RAU patients and S. mutans-stimulated PR of T-cells from active RAU patients. These results suggest that THL can modulate the antigen-stimulated PR of PBMC and T-cells from RAU patients. Therefore, it may be a potential immunoceutical agent for treatment of RAU.


Dr. Wang Zhen Guo (left) is in the First Annual Ten Best Youths of China awards. (1990)	Medaille De Chevalier*	Diplome D'Officier*	Diplome De Chevalier*	Diplome Du Merite De L'invention*
*Awarded in the 38th World Fair for Invention, Research and Industrial Innovation held in Brussels.
1989 - Best Individual Invention at the 38th Brussels Eureka World Fair for Invention. (1) Medal for Honor by the King of Belgium. (2) General Medal by the King of Belgium. (3) Knights Medal by the King of Belgium.
1990 - Recipient of the Second Annual Technology Entrepreneurs Award in China
1990 - Recipient of the National Distinguished Contribution Award for Outstanding Young Professional
1991 - Recipient of the National Outstanding Achievement Award for Self-Proficiency
1992- Community Excellence Award for Technology Entrepreneur in China
1992 - Recognized by China as an Outstanding Intelligent National
1992 - Became the First Chinese Traditional Doctor Recorded in the Who's Who of Intellectuals by the International Biographical Center at Cambridge, England.
1995 - National Crucial New Product of the Year Award - Tien Hsien Liquid No. 1
1997 - Only Chinese Pharmacologist invited to lecture at the Third Annual Japan Cancer Expo conducted by the American Cancer Control Association.
1998 - Published the latest in Anti-Cancer Research and Developments in the Fourth Annual Japan Cancer Expo conducted by the American Cancer Control Association